Epileptic seizures are more common in males than in females. One of the areas that have recently been implicated in the higher susceptibility of males to seizures is the substantia nigra reticulata SNR. Several studies support the existence of phenotypic differences between male and female infantile SNR neurons and particularly in several aspects of the GABAergic system, including its ability to control seizures. We have recently found that at postnatal day PN rats, which are equivalent to infants, activation of GABA A receptors has different physiological effects in male and female SNR neurons.
Sex- and age-related changes in GABA signaling components in the human cortex
Sex, Hormones and GABA in Stress Induced Anhedonia in Depression - Diego Pizzagalli
One of the most important ways that you can continue to look, feel, and live younger occurs when you have a vibrant and active sex life. Once you lose the interest -- or ability -- to enjoy sex, almost everyone ages very quickly, and often prematurely. Youthfulness is identified with high sexual activity, so no matter what age we are at we should be experiencing a life full of intimacy, touch, and love. However, as we get older, this is not always the case. When your brain is at peak health, you will want to experience the joys of sex all the time.
Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression
Que sont les tics et les tocs? The role of GABA receptor subtypes in sexual behavior has been analyzed in previous pharmacological studies. These data further support the hypothesis that the GABAA receptor is not involved in the control of male sexual behavior.
Major depressive disorder MDD is the leading cause of disease burden worldwide and women have a 2-fold risk higher than men. Despite this, little is known about the neurobiological mechanisms associated with the sex-dependent emergence of MDD and in what form they persist after full remission. Preclinical studies have demonstrated dysregulated hypothalamic pituitary adrenal HPA circuitry i.